The U.S. Bureau of Prisons said Epstein was found unresponsive in his cell in the Metropolitan Correctional Center early Saturday.
Staff tried to revive him, and he was transported to a local hospital for treatment. He was pronounced dead at the hospital.
Epstein had been held in the jail’s Special Housing Unit, a heavily secured part of the facility that separates high-profile inmates from the general population, but his death is likely to raise questions about how the Bureau of Prisons ensures the welfare of high-profile inmates.
Attorney General William Barr said he was “appalled” by the news.
Before he took his own life, Epstein has been taken off suicide watch, according to a person familiar with the matter who spoke to Maybach Media. The person wasn’t authorized to discuss the matter publicly and spoke on condition of anonymity.
Epstein had previously been injured with bruises to the neck while in custody, though it was not clear if those were self-inflicted or the result of an assault.
The FBI and the Office of the Inspector General at the Department of Justice will investigate his death.